ZM 447439
Aurora B激酶抑制剂；N-[4-[[6-甲氧基-7-[3-(4-吗啉基)丙氧基]-4-喹唑啉基]氨基]苯基]苯甲酰胺
ZM-447439
Aurora B激酶抑制剂；N-[4-[[6-甲氧基-7-[3-(4-吗啉基)丙氧基]-4-喹唑啉基]氨基]苯基]苯甲酰胺
ZM-447439
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产品编号： CZR487000
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CAS号： 331771-20-1
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分子式：C29H31N5O4
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分子量：513.59
英文别名：
N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide
熔点：
117-120°C
可溶性：
DMSO,
性状：
Pale Yellow Solid
SMILES：
CCOC(COC1C=C2C=CC(=NC2=C(NS(C2C=CC(C)=CC=2)(=O)=O)C=1)C)=O
储存条件：
Refrigerator
参考文献：
Ditchfield, C., et al.: J. Cell Biol., 161, 267 (2003), Long, Z.J., et al.: J. Cell Cycle, 7, 1473 (2008), Walsby, E., et al.: Haematologica, 93, 662 (2008),
It is a potent and selective inhibitor of Aurora B kinase. Cells treated with ZM-447439 progress through interphase, enter mitosis and assemble bipolar spindles but chromosome alignment, segregation and cytokinesis all fail. It induces apoptosos in Hep2 cancer cells and in acute myeloid leukemia cell lines but its propensity to induce polyploidy does not inevitably result in apoptosis.
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