ZD-7288-d3
Ih通道抑制剂内标物
ZD 7288-d3
Ih通道抑制剂内标物
ZD 7288-d3
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产品编号： CZR157502
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相关CAS号：133059-99-1（未标记）
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分子式：C15H18D3ClN4
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分子量：295.83
英文别名：
ICI-D 7288-d3；N-Ethyl-1,6-dihydro-1,2-dimethyl-6-(methylimino)-N-phenyl-4-pyrimidinamine-d3 Hydrochloride
SMILES：
COC1C=C(C(=O)NS(C2C=CC=CC=2C)(=O)=O)C=CC=1CC1C2C(=CC=C(NC(=O)OC3CCCC3)C=2)N(C)C=1
参考文献：
Vera, P., et al.: Brain Res. Bull., 29, 651 (1992), Su, X., et al.: J. Neurophysiol., 77, 1566 (1997), Ishii, T., et al.: J. Biol. Chem., 274, 12835 (1999), Masuda, N., et al.: Brain Res., 1096, 40 (2006),
Labelled ZD 7288 (Z157500). ZD 7288 is a selective Ih channel inhibitor. ZD 7288 is an sino-atrial node function modulator; blocks the hyperpolarization activated cation current If. ZD 7288 blocks Ih in central neurons. ZD 7288 increases NMDA-evoked noradrenalin release in rat brain in vitro.
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