ZD-7288
Ih通道抑制剂
ZD 7288
Ih通道抑制剂
ZD 7288
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产品编号： CZR157500
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CAS号： 133059-99-1
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分子式：C15H21ClN4
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分子量：292.81
英文别名：
ICI-D 7288；N-Ethyl-1,6-dihydro-1,2-dimethyl-6-(methylimino)-N-phenyl-4-pyrimidinamine Hydrochloride
SMILES：
OC1C=C2C(C=C(C(OCC)=O)C(=O)O2)=CC=1
参考文献：
Vera, P., et al.: Brain Res. Bull., 29, 651 (1992), Su, X., et al.: J. Neurophysiol., 77, 1566 (1997), Ishii, T., et al.: J. Biol. Chem., 274, 12835 (1999), Masuda, N., et al.: Brain Res., 1096, 40 (2006),
ZD 7288 is a selective Ih channel inhibitor. ZD 7288 is an sino-atrial node function modulator; blocks the hyperpolarization activated cation current If. ZD 7288 blocks Ih in central neurons. ZD 7288 increases NMDA-evoked noradrenalin release in rat brain in vitro.
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