YE-120
GPR35激动剂；2-[3-氰基-5-(3,4-二氯苯基)-4,5-二甲基-2(5H)-呋喃亚基]丙二睛
YE-120
GPR35激动剂；2-[3-氰基-5-(3,4-二氯苯基)-4,5-二甲基-2(5H)-呋喃亚基]丙二睛
YE-120
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产品编号： CYR100700
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CAS号： 383124-82-1
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分子式：C16H9Cl2N3O
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分子量：330.17
英文别名：
2-[3-Cyano-5-(3,4-dichlorophenyl)-4,5-dimethyl-2(5H)-furanylidene]propanedinitrile
参考文献：
Okumura, S., et al.: Cancer Sci., 95, 131 (2004); Wang, J., et al.: J. Biol. Chem., 281, 22021 (2006); Yang, Y., et al.: Pharmacology, 86, 1 (2010); Deng, et al.: J. Med. Chem., 54 7385 (2011);
YE-120 is a GPR35 agonist (EC50 = 32 nM in DMR assays). YE-120 also displays partial agonist activity in a β-arrestin translocation assay (EC50 = 10.2 μM).
GPR35 is a Class A, rhodopsin-like G protein-coupled receptor which is predominantly expressed in immune and gastrointestinal tissue, with notable expression in the ileum (rat and human GPR35), the spleen (rat and murine GPR35) and the pancreas (human GPR35).
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