XL518
木糖醇-13C5
XL 518
木糖醇-13C5
XL 518
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产品编号： CXR746250
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CAS号： 934660-93-2
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分子式：13C5H12O5
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分子量：157.11
英文别名：
GDC 0973；[3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl][3-hydroxy-3-[(2S)-2-piperidinyl]-1-azetidinyl]methanone
SMILES：
OC1([C@H]2NCCCC2)CN(C(C2=C(NC3=C(F)C=C(I)C=C3)C(F)=C(F)C=C2)=O)C1
参考文献：
Rosen, L.S. et al.: J. Clin. Oncol., 26, 14585 (2008);
A potent, selective, orally bioavailable inhibitor of MEK1, a component of the RAS/RAF/MEK/ERK pathway. It inhibits proliferation and stimulates apoptosis in a variety of human tumor cell lines. In preclinical xenograft models, oral administration of XL518 results in sustained inhibition of pERK in tumor tissue, but not brain tissue, leading to tumor growth inhibition and regression at well tolerated doses.
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