XAV-939
TNKS抑制剂
XAV 939
TNKS抑制剂
XAV 939
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产品编号： CXR744000
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CAS号： 284028-89-3
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分子式：C14H11F3N2Os
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分子量：312.31
英文别名：
1,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one；NVP-XAV-939
SMILES：
C1C2=C(OC3C(C2C(O)=O)=CC=CC=3)C=CC=1
参考文献：
Huang, S. et al.: Nature, 461, 614 (2009); Wang, H. et al.: ACS Chem. Biol., 6, 192 (2011); Adles, M.E. et al.: Sci. Signal., 91, ec326 (2009);
A tankyrase (TNKS) inhibitor that antagonizes Wnt signaling via stimulation of β-catenin degradation and stabilization of axin. XAV 939 inhibits proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1.
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