VX-745
p38αMAPK抑制剂
VX-745
p38αMAPK抑制剂
VX-745
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产品编号： CVR900500
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CAS号： 209410-46-8
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分子式：C19H9Cl2F2N3Os
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分子量：436.26
英文别名：
5-(2,6-Dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one
熔点：
259-262°C (dec.)
可溶性：
Chloroform, DMSO, Methanol
性状：
Pale Yellow Solid
SMILES：
FC1=CC(F)=C([C@](O)(CN2N=CN=C2)[C@](C)(C2=C(F)C=NC=N2)[H])C=C1
储存条件：
-20˚C Freezer
参考文献：
Haddad, J.J.: Curr. Opin. Invest. Drugs, 2, 1070 (2001); Duffy, J.P. et al.: ACS Med. Chem. Lett., 2, 758 (2011); Bagley, M.C. et al.: Pharmaceuticals, 3, 1842 (2010);
VX 745 is a potent and selective inhibitor of p38α mitogen-activated protein (MAP) kinase. VX 745 is a potential anti-inflammatory agents. Studies suggest that VX 745 may be useful in the treatment of Werner syndrome.
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