维罗非尼-d5
维罗非尼-d5
Vemurafenib-d5
维罗非尼-d5
Vemurafenib-d5
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产品编号： CVR118502
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CAS号： 1365986-90-8
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分子式：C23H13D5ClF2N3O3S
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分子量：494.95
英文别名：
N-[3-[[5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide-d5; PLX 4032-d5; RG 7204-d5; Ro 51-85426-d5;
SMILES：
CCOC1C=CC(C(CN2CCN(C(C([2H])([2H])[2H])([2H])[2H])CC2)=O)=CC=1C1=NC(=O)C2=C(N=C(CCC)N2N1)C
参考文献：
Halaban, R. et al.: Pigm. Cell. Melonoma Res., 23, 190 (2010); Yang, H. et al.: Cancer Res., 70, 5518 (2010); Comin-Anduix, B. et al.: Clin. Cancer Res., 16, 6040 (2010);
Labelled Vemurafeni, a selective BRAFV600E kinase inhibitor; an antitumor agent. Vemurafenib functions by inhibiting the proliferation and mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase and ERK phosphorylation in a panel of tumor cell lines, including melanoma cell lines expressing BRAFV600E or other mutant BRAF proteins altered at codon 600.
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