维罗非尼
维罗非尼
Vemurafenib
维罗非尼
Vemurafenib
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产品编号： CVR118500
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CAS号： 918504-65-1
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分子式：C23H18ClF2N3O3S
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分子量：489.92
英文别名：
N-[3-[[5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide; PLX 4032; RG 7204; Ro 51-85426;
熔点：
266-268°C
可溶性：
DMSO, Methanol
性状：
Off-White Solid
SMILES：
CCN1CCN(CC(C2C=CC(OCC)=C(C3=NC(=O)C4=C(N=C(CCC)N4N3)C)C=2)=O)CC1
储存条件：
Refrigerator
参考文献：
Halaban, R. et al.: Pigm. Cell. Melonoma Res., 23, 190 (2010); Yang, H. et al.: Cancer Res., 70, 5518 (2010); Comin-Anduix, B. et al.: Clin. Cancer Res., 16, 6040 (2010);
Vemurafenib selective BRAFV600E kinase inhibitor; an antitumor agent. Vemurafenib functions by inhibiting the proliferation and mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase and ERK phosphorylation in a panel of tumor cell lines, including melanoma cell lines expressing BRAFV600E or other mutant BRAF proteins altered at codon 600.
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