凡德他尼
凡德他尼
Vandetanib
凡德他尼
Vandetanib
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产品编号： CVR097100
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CAS号： 443913-73-3
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分子式：C22H24BrFN4O2
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分子量：475.35
英文别名：
ZD 6474; Zactima
熔点：
240-2430C
可溶性：
Methanol
性状：
Off-White to Pale Yellow Solid
SMILES：
CCCCC(N([C@H](C(=O)O)C(C)C)CC1=CC=C(C2=CC=CC=C2C2N=NNN=2)C=C1)=O
储存条件：
-20˚C Freezer
参考文献：
Bruns, C., et al.: Clin. Cancer Res., 6, 1936 (2000), Hennequin, L., et al.: J. Med. Chem., 45, 1300 (2002), Park, M., et al.: J. Biol. Chem., 278, 50624 (2003), Arao, T., et al.: Cancer Res., 64, 9101 (2004), Prueitt, R., et al.: Int. J. Cancer, 120, 796
Vandetanib is a once-daily oral inhibitor of vascular endothelial growth factor receptor-2 and epidermal growth factor receptor kinase activity. The activity of Vandetanib plus Docetaxel was assessed in patients with previously treated non-small-cell lung cancer (NSCLC).
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