U-44069
乌利司他乙酸酯；醋酸乌利司他
U-44069
乌利司他乙酸酯；醋酸乌利司他
U-44069
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产品编号： CUR100200
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CAS号： 56985-32-1
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分子式：C30H37NO4
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分子量：475.62
英文别名：
(11β)-17-(Acetyloxy)-11-[4-(dimethylamino)phenyl]-19-norpregna-4,9-diene-3,20-dione; 17α-Acetoxy-11β-(4-dimethylaminophenyl)-19-norpregna-4,9-dien-3,20-dione; CDB 2914; EllaOne; HRP 2000; RTI 3021-012; RU 44675; VA 2914;
SMILES：
CCCCC[C@@H](/C=C/[C@H]1[C@@H]2CO[C@@H](C2)[C@@H]1C/C=C\CCCC(=O)O)O
参考文献：
Miller, D., et al.: J. Biol. Chem., 260, 1006 (1985), Ruan, K., et al.: J. Biol. Chem., 268, 19483 (1993), So, S., et al.: J. Biol. Chem., 278, 10922 (2003), Ruan, K., et al.: Biochemistry, 47, 680 (2008),
U-44069 is a stable analog of the endoperoxide PGH2, and a TP receptor agonist. U-44069 stimulates shape change in human platelets without a measurable increase in [Ca2+] with an EC50 of 1.8 nM. U-44069 has an EC50 of 3 µM and 54 nM for platelet aggregation and phosphatidate formation in human platelets, respectively.
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