替匹法尼
替匹法尼
Tipifarnib
替匹法尼
Tipifarnib
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产品编号： CTR444880
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CAS号： 192185-72-1
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分子式：C27H22Cl2N4O
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分子量：489.4
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EINECES：243-014-4
英文别名：
(R)-(+)-R 115777；Zarnestra
熔点：
211-213°C (dec.)
可溶性：
Chloroform, Methanol
性状：
Off-White to Pale Beige Solid
SMILES：
CCS(CCN1C(C)=NC=C1[N+]([O-])=O)(=O)=O
储存条件：
-20˚C Freezer
参考文献：
David, E., et al.: Blood, 116, 5285 (2010); Nagai, T., et al.: Leukemia Res., 34, 1057 (2010); Hong, D., et al.: Clin. Cancer Res., 15, 7061 (2009)
A farnesyltransferase inhibitor. Sensitizes human multiple myeloma cell to proteasome inhibition by blocking degradation of bortezomib(B675700)-induced aggresomes. Also shown to inhibit the growth of myeloid leukemia cell lines and primary leukemia cells
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