TH-302
N,N'-双(2-溴乙基)膦酸二胺 (1-甲基-2-硝基-1H-咪唑-5-基)甲酯
TH-302
N,N'-双(2-溴乙基)膦酸二胺 (1-甲基-2-硝基-1H-咪唑-5-基)甲酯
TH-302
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产品编号： CTR338200
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CAS号： 918633-87-1
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分子式：C9H16Br2N5O4P
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分子量：449.04
英文别名：
N,N'-Bis(2-bromoethyl)phosphorodiamidic Acid (1-Methyl-2-nitro-1H-imidazol-5-yl)methyl Ester
参考文献：
Meng, F. et al.: Mol. Cancer Ther., 11, 740 (2012); Liu, Q. et al.: Cancer Chemother. Pharmacol., 69, 1487 (2012); Sun, J.D. et al.: Clin. Cancer Res., 18, 758 (2012);
TH-302 is a 2-nitroimidazole triggered hypoxia-activated prodrug (HAP) of bromo-isophosphoramide mustard. Studies have shown that TH-302 treatment exhibited hypoxia-selective cytotoxicity and DNA damage in human cancer cell
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