TAK-960
PLK1抑制剂；4-[(9-环戊基-7,7-二氟-6,7,8,9-四氢-5-甲基-6-酮基-5H-嘧啶并[4,5-b][1,4]二氮杂卓-2-基)氨基]-2-氟-5-甲氧基-N-(1-甲基-4-哌啶基)苯甲酰胺
TAK 960
PLK1抑制剂；4-[(9-环戊基-7,7-二氟-6,7,8,9-四氢-5-甲基-6-酮基-5H-嘧啶并[4,5-b][1,4]二氮杂卓-2-基)氨基]-2-氟-5-甲氧基-N-(1-甲基-4-哌啶基)苯甲酰胺
TAK 960
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产品编号： CTR004940
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CAS号： 1137868-52-0
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分子式：CH34F3N7O3
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分子量：561.6
英文别名：
4-[(9-Cyclopentyl-7,7-difluoro-6,7,8,9-tetrahydro-5-methyl-6-oxo-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-2-fluoro-5-methoxy-N-(1-methyl-4-piperidinyl)benzamide
SMILES：
CN1C(=O)[C@H]2N(C(=O)C1)[C@@H](C3=CC4=C(OCO4)C=C3)C5=C(C2)C6C(=CC=CC=6)N5
参考文献：
Hikichi, Y. et al.: Mol. Cancer Ther., 11, 700 (2012); Chen, S. et al.: Bioorg. Med, Chem. Lett., 22, 1247 (2012);
TAK-960 is a potent and selective inhibitor of polo-like kinase 1 (PLK1), a serine/threonine protein kinase involved in key processes during mitosis. TAK-960 has shown activity in several tumor cell lines, including those that express multidrug-resistant
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