舒林酸硫化物-d6
舒林酸杂质C-d6(USP)；舒林酸硫化物-d6 (混合物)
Sulindac Sulfide-d6
舒林酸杂质C-d6(USP)；舒林酸硫化物-d6 (混合物)
Sulindac Sulfide-d6
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产品编号： CSR699222
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相关CAS号：49627-27-2（未标记）
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分子式：C20H11D6FO2S
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分子量：346.45
英文别名：
(Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic Acid-d6;
SMILES：
OC1C(/N=N/C2C=CC(S(NC3C=CC=CN=3)(=O)=O)=CC=2)=CC=CC=1C(O)=O
参考文献：
Hermann, C., et al.: Oncogene, 17, 1769 (1998); Lim, T.J., et al.: Biochem. Pharmacol., 58, 1097 (1999); Zhang, Z. and DuBois, R.N.: Gastroenterology, 118, 1012 (2000);
Labelled analogue of Sulindac Sulfide, an active metabolite of Sulindac. Inhibits cyclooxygenase, but induces apoptosis by a cyclooxygenase-independent mechanism. Inhibition of Ras activation of Ref-1. Impairs nucleotide exchange on Ras by CDC25 and accelerates Ras hydrolysis of GTP by p120GAP.
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