舒林酸相关化合物C
舒林酸杂质C(USP)；舒林酸硫化物
Sulindac Related Compound C
舒林酸杂质C(USP)；舒林酸硫化物
Sulindac Related Compound C
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产品编号： CSR699220
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CAS号： 49627-27-2
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分子式：C20H17FO2S
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分子量：340.41
英文别名：
Sulindac Sulfide
熔点：
177-182°C
可溶性：
Acetone, Dichloromethane, DMSO, Methanol
性状：
Yellow Solid
SMILES：
SCCNS(C1C=CC(C2C3C=CC(=CC=3OC3=C/C(=[N+](\CC)/CC)/C=CC=23)N(CC)CC)=C(S([O-])(=O)=O)C=1)(=O)=O
储存条件：
Hygroscopic, -20°C Freezer, Under inert atmosphere
参考文献：
Hermann, C., et al.: Oncogene, 17, 1769 (1998), Lim, T.J., et al.: Biochem. Pharmacol., 58, 1097 (1999), Zhang, Z. and DuBois, R.N.: Gastroenterology, 118, 1012 (2000),
An active metabolite of Sulindac. Inhibits cyclooxygenase, but induces apoptosis by a cyclooxygenase-independent mechanism. Inhibition of Ras activation of Ref-1. Impairs nucleotide exchange on Ras by CDC25 and accelerates Ras hydrolysis of GTP by p120GAP.
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