SNX-2112
Hsp90抑制剂；4-(6,6-二甲基-4-酮基-3-(三氟甲基)-4,5,6,7-四氢吲唑-1-基)-2-((1r,4r)-4-羟基环基氨基)苯甲酰胺
SNX-2112
Hsp90抑制剂；4-(6,6-二甲基-4-酮基-3-(三氟甲基)-4,5,6,7-四氢吲唑-1-基)-2-((1r,4r)-4-羟基环基氨基)苯甲酰胺
SNX-2112
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产品编号： CSR590250
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CAS号： 908112-43-6
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分子式：C23H27F3N4O3
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分子量：464.48
英文别名：
PF 04928473；4-(6,6-Dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydroindazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide
SMILES：
ClC1C=CC(C2=CSC(NC3C=CC(O)=CC=3)=N2)=CC=1
参考文献：
Liu, K.S., et al.: Oncol. Reports., 27, 1904 (2012); Wang, S.X., et al.: BioSci. Biotech. Biochem., 75, 1540 (2011); Bachleitner, H., et al.: Clinical, Cancer, Rsch., 17, 12 (2011);
SNX-2112 is a selective heat shock protein 90 (Hsp90) inhibitor which can exert a potent anticancer activity. Studies demonstates that SNX-2112 can exhibit a potent anticancer activity against B16 melanoma cells both in vitro and in vivo, by inhibiting cell proliferation and inducing cell cycle arrest and apoptosis in a mechanism dependent on the degredation of Hsp90 client proteins.
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