SEN 12333
nAChR激动剂；N-[4-(3-吡啶基)苯基]-4-吗啉戊酰胺
SEN-12333
nAChR激动剂；N-[4-(3-吡啶基)苯基]-4-吗啉戊酰胺
SEN-12333
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产品编号： CSR258600
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CAS号： 874450-44-9
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分子式：C20H25N3O2
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分子量：339.43
英文别名：
WAY 317538；N-[4-(3-Pyridinyl)phenyl]-4-morpholinepentanamide
SMILES：
OC1C=CC(C)=C(CC[C@@H]2C(=O)CC[C@@]3(C(CC[C@@H]23)=O)C)C=1
参考文献：
Roncarati, et al.: J. Pharmacol. Exp. Ther., 329, 459 (2009); Beina,t et al.: Bioorg. Med. Chem. Lett., 22, 2380 (2012);
SEN 12333 is a nicotinic acetylcholine receptor (nAChR) agonist. SEN 12333 displays functional antagonism at histamine H3 receptors (IC50 = 103 nM) and weak agonist activity at human ganglionic α3 nAChRs (IC50 = 8.5 μM). Neuroprotective in a rodent model of quisqualic acid-induced cholinergic degeneration. SEN 12333 is a brain penetrant and orally bioavailable.
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