SB-505124
ALK5抑制剂；2-[5-(1,3-苯并二氧戊环-5-基)-2-(1,1-二甲基乙基)-1H-咪唑-4-基]-6-甲基吡啶
SB 505124
ALK5抑制剂；2-[5-(1,3-苯并二氧戊环-5-基)-2-(1,1-二甲基乙基)-1H-咪唑-4-基]-6-甲基吡啶
SB 505124
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产品编号： CSR154680
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CAS号： 694433-59-5
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分子式：C20H21N3O2
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分子量：416.64
英文别名：
2-[5-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)-1H-imidazol-4-yl]-6-methylpyridine
SMILES：
CC1C2(OCC(C)CC2)OC2CC3C(C)(C12)CCC1C3CCC2C1(C)CCC(O)C2
参考文献：
Goto, N. et al.: Cancer Sci., 102, 1501 (2011); DaCosta, B.S. et al.: Mol Pharmacol., 65, 744 (2004);
SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptor ALK5 and as well as being a selective inhibitor of ALK4 but with less potency. SB-505124 blocks TGF-β–induced apoptosis of FaO cells and NRP 154 cells in a concentration-dependent manner. SB-505124 has been shown to suppress the migration and invasion of breast cancer MCF-7-M5 cells.
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