RWJ-67657
p38MAPK抑制剂；4-[4-(4-氟苯基)-1-(3-苯丙基)-5-(4-吡啶基)-1H-咪唑-2-基]-3-丁炔-1-醇
RWJ-67657
p38MAPK抑制剂；4-[4-(4-氟苯基)-1-(3-苯丙基)-5-(4-吡啶基)-1H-咪唑-2-基]-3-丁炔-1-醇
RWJ-67657
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产品编号： CRR925200
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CAS号： 215303-72-3
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分子式：C27H24FN3O
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分子量：425.5
英文别名：
JNJ 3026582；4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol
参考文献：
Fijen, J. et al.: Clin. Exp. Immunol., 124, 16 (2001); Westra, J. et al.: Int. Immunopharmacol., 5, 1259 (2005); Westra, J. et al.: Ann. Rheum. Dis., 63, 1453 (2004);
RWJ-67657 is a p38 mitogen-activated protein-kinase (p38MAPK) inhibitor. Studies show that RWJ-67657 might provide a useful tool to intervene in the deranged immune response in sepsis and other inflammatory diseases. RWJ 67657 has been shown to inhibit chemokine production and E-selectin expression in activated endothelial cells,
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