Ruboxistaurin Hydrochloride
JAK1/JAK2抑制剂内标物
Ruboxistaurin Hydrochloride
JAK1/JAK2抑制剂内标物
Ruboxistaurin Hydrochloride
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产品编号： CRR701525
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CAS号： 169939-93-9
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分子式：C1613CH18N415N2
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分子量：309.34
英文别名：
β-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile; INCB 018424-13C,15N2;
SMILES：
O=C1C2C3C4C(=CC=CC=4)N(CCC(CN(C)C)OCCN4C5C(C(=C4)C=2C(=O)N1)=CC=CC=5)C=3.[H]Cl
参考文献：
Miller, J., et al.: Diabetes Metab. Rev., 13, 37 (1997),
Ruboxistaurin is a protein kinase C (PKC) β inhibitor, exhibits significant anti-angiogenic activity that reduces the response of vascular endothelial cells to stimulation by vascular endothelial growth factor (VEGF). Ruboxistaurin is used in treatment of diabetic microvascular complications.
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