RTI-336
(1R,2S,3S,5S)-3-(4-氯苯基)-8-甲基-2-[3-(4-甲苯基)-5-异恶唑基]-8-氮杂双环[3.2.1]辛烷盐酸盐
RTI-336
(1R,2S,3S,5S)-3-(4-氯苯基)-8-甲基-2-[3-(4-甲苯基)-5-异恶唑基]-8-氮杂双环[3.2.1]辛烷盐酸盐
RTI-336
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产品编号： CRR701250
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CAS号： 204069-50-1
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分子式：C24H26Cl2N2O
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分子量：429.38
英文别名：
RTI 4229-336
SMILES：
[C@H]1([C@H]([C@@H]([C@H](C(O[C@@H]([C@](O)(C)[C@H](O)[C@@H](C)C(=NOCOCCOC)[C@H](C)C[C@]1(O)C)CC)=O)C)O[C@@H]1O[C@H]([C@H](O)[C@](C)(OC)C1)C)C)O[C@@H]1O[C@@H](C[C@H](N(C)C)[C@H]1O)C
参考文献：
Carroll, F.I. et al.: AAPS J., 8, E196 (2006); Czoty, P.W. et al.: Pharmacol. Biochem. Behav., 96, 274 (2010); Carroll, F. et al.: Eur. J. Pharmacol., 553, 149 (2006);
RTI-336 is a a phenyltropane cocaine analog that acts selective dopamine reuptake inhibitor. RTI-336 binds to the dopamine transporter with around 20 times the affinity of cocaine but produces relatively mild stimulant effects. RTI-336 is a potential candidate for pharmacotherapy for treating cocaine addiction.
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