RS-127445 盐酸盐
5-HT2B受体拮抗剂；2-氨基-4-(4-氟萘-1-基)-6-异丙基嘧啶盐酸盐
RS-127445 Hydrochloride
5-HT2B受体拮抗剂；2-氨基-4-(4-氟萘-1-基)-6-异丙基嘧啶盐酸盐
RS-127445 Hydrochloride
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产品编号： CRR700930
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CAS号： 199864-86-3
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分子式：C17H17ClFN3
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分子量：317.79
英文别名：
2-Amino-4-(4-fluoronaphth-1-yl)-6-isopropylpyrimidine Monohydrochloride
SMILES：
[Br-].FC1C=CC(C2C(C[P+](C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)=C(C(C)C)N=C(N(C)S(C)(=O)=O)N=2)=CC=1
参考文献：
Mokrosz, J., et al.: Pharmazie, 49, 801 (1994), Hoyer., et al.: Pharmacol. Rev., 46, 157 (1994),
Martin., et al.: Neuropharmacol., 33, 261 (1994),
RS-127445 is a selective; high affinity; orally bioavailable serotonin 5-HT2B receptor antagonist. RS-127445 was found to have nanomolar affinity for the 5-HT2B receptor (pKi=9.5) and 1,000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites.
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