Roscovitine
CDKs抑制剂
(R)-Roscovitine
CDKs抑制剂
(R)-Roscovitine
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产品编号： CRR684000
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CAS号： 186692-46-6
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分子式：C19H26N6O
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分子量：354.45
英文别名：
R-Roscovitine；Seliciclib；CYC 202
参考文献：
De Azevedo, W.F. et al.: Eur. J. Biochem., 43, 518 (1997); Planchais, S. et al.: Plant J., 12, 191 (1997); Mgbonyebi O.P. et al.: Anticancer Res., 18, 751 (1998); MacCallum, D.E. et al.: Cancer Res., 65, 5399 (2005);
Roscovitine is a potent and selective inhibitor of cyclin-dependent kinases (CDKs). Roscovitine has been found to produce apoptosis in treated cancerous cells of non-small cell lung cancer (NSCLC) and other cancers. Studies show that Roscovitine displays increased anti-mitotic activity at the G1/S and G2/M phases of the cell cycle. Roscovitine maybe useful in the treatment of non-small cell lung cancer (NSCLC), leukemia, HIV infection, herpes simplex infection, and the mechanisms of chronic inflammation disorders.
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