Ro-106-9920-d5
NF-κB活性抑制剂内标物；6-(苯基-d5-亚磺酰)四唑并[1,5-b]哒嗪
Ro-106-9920-d5
NF-κB活性抑制剂内标物；6-(苯基-d5-亚磺酰)四唑并[1,5-b]哒嗪
Ro-106-9920-d5
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产品编号： CRR637502
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相关CAS号：62645-28-7（未标记）
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分子式：C10H2D5N5Os
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分子量：250.29
英文别名：
6-[(Phenyl-d5)sulfinyl]tetrazolo[1,5-b]pyridazine
SMILES：
OCCN(C1C=CC(N2C[C@H](CNC(C3=CC=C(Cl)S3)=O)OC2=O)=CC=1)C(CO)=O
参考文献：
Leslie, C., et al.: J. Biol. Chem., 272, 16709 (1997), Liu, F., et al.: Thromb. Res., 106, 199 (2002), Swinney, et al.: J. Biol. Chem., 277, 23573 (2002), Adler, D., et al.: J. Clin. Invest., 118, 2121 (2008),
Labelled Ro 106-9920 (R637500). Ro 106-9920 is an inhibitor of NF-κB activation, possibly via selective inhibition of LPS- and TNF-α-induced IκBα ubiquitination (IC50 = 3 μM). Ro 106-9920 blocks subsequent production of TNF-α, IL-1β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo. Also weakly inhibits EGFR, 5-lipoxygenase and iNOS.
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