Ro 106-9920
NF-κB活性抑制剂；6-(苯基亚磺酰)四唑并[1,5-b]哒嗪
Ro 106-9920
NF-κB活性抑制剂；6-(苯基亚磺酰)四唑并[1,5-b]哒嗪
Ro 106-9920
-
产品编号： CRR637500
-
CAS号： 62645-28-7
-
分子式：C10H7N5Os
-
分子量：245.26
英文别名：
6-(Phenylsulfinyl)tetrazolo[1,5-b]pyridazine
参考文献：
Leslie, C., et al.: J. Biol. Chem., 272, 16709 (1997), Liu, F., et al.: Thromb. Res., 106, 199 (2002), Swinney, et al.: J. Biol. Chem., 277, 23573 (2002), Adler, D., et al.: J. Clin. Invest., 118, 2121 (2008),
Ro 106-9920 is an inhibitor of NF-κB activation, possibly via selective inhibition of LPS- and TNF-α-induced IκBα ubiquitination (IC50 = 3 μM). Ro 106-9920 blocks subsequent production of TNF-α, IL-1β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo. Also weakly inhibits EGFR, 5-lipoxygenase and iNOS.
搜索质检报告(COA)
搜索MSDS
