Romidepsin
罗米地辛；罗咪酯肽
Romidepsin
罗米地辛；罗咪酯肽
Romidepsin
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产品编号： CRR425060
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CAS号： 128517-07-7
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分子式：C24H36N4O6S2
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分子量：540.7
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EINECES：246-110-4
英文别名：
Antibiotic FR 901228；FK 228
熔点：
219-224°C
可溶性：
Chloroform
性状：
Pale Yellow Solid
SMILES：
OC(C(O)C(O)CO)C=O
储存条件：
Amber Vial, -20°C Freezer, Under Inert Atmosphere
参考文献：
Ueda, H., et al.: J. Antibiot., 47, 301 (1994), Weidle, U., et al.: Anticancer Res., 20, 1471 (2000), Kitazono, M., et al.: Cancer Res., 61, 6328 (2001), Sandor, V., et al.: Clin. Cancer Res., 8, 718 (2002),
Romidepsin is a histone deacetylase inhibitor that can alter chromatin structure and gene transcription leading to multiple changes in cellular protein production. This may result in cell cycle arrest and tumor growth inhibition. Romidepsin has shown anti-proliferative activity in vitro against multiple mouse and human tumor cell lines and in vivo in human tumor xenograft models. Romidepsin can be administered with a second agent, such as a cytotoxic agent, a steroidal agent, a proteasome inhibitor, or a kinase inhibitor.
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