瑞沙托维
瑞沙托维
Resatorvid
瑞沙托维
Resatorvid
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产品编号： CRR144570
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CAS号： 243984-11-4
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分子式：C15H17ClFNO4S
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分子量：361.82
英文别名：
(6R)-6-[[(2-Chloro-4-fluorophenyl)amino]sulfonyl]-1-cyclohexene-1-carboxylic Acid Ethyl Ester; TAK 242;
参考文献：
Abraham, E., et al.: Lancet, 351, 929 (1998), Akashi, S., et al.: J. Exp. Med., 198, 1035 (2003), Akira, S., et al.: Immunol. Lett., 85, 85 (2003), Medvedev, A., et al.: J. Biol. Chem., 282, 16042 (2007),
Resatorvid is a novel selective Toll-like receptor 4 signal transduction inhibitor. Resatorvid inhibits various kinds of inflammatory mediators such as nitric oxide (NO), tumor necrosis factor (TNF)-α, interleukin (IL)-1, IL-6, IL-10, macrophage inhibitory protein (MIP)-2 and prostaglandin E2 from lipopolysaccharide (LPS)-stimulated macrophages.
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