喹夫拉朋钠
喹夫拉朋钠
Quiflapon Sodium
喹夫拉朋钠
Quiflapon Sodium
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产品编号： CQCRR535400
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CAS号： 147030-01-1
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分子式：C34H34ClN2NaO3S
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分子量：609.15
英文别名：
1-[(4-Chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(2-quinolinylmethoxy)-1H-Indole-2-propanoic Acid Sodium Salt; MK 591;
SMILES：
OC1C=CC(C2OC3=CC(=CC(O)=C3C(=O)C=2O)O[C@@H]2O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]2O)=CC=1O
参考文献：
Carson, J., et al.: Cancer Res., 59, 1449 (1999), Gupta, S., et al.: Cancer, 91, 737 (2001), Jema, A., et al.: Cancer J. Clin., 57, 43 (2007), Ochoa, J., et al.: Carcinogenesis, 25, 1185 (2004),
Quiflapon is a synthetic compound which specifically inhibits the activity of 5-Lox and is currently under development for the treatment of asthma. Also, Quiflapon, a leukotriene biosynthesis inhibitor, induces apoptosis in prostate cancer cells.
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