PU-H71 一水合物
HSP90抑制剂；6-氨基-8-[(6-碘-1,3-苯并二氧五环-5-基)硫]-N-(1-甲基乙基)-9H-嘌呤-9-丙胺一水合物
PU-H71 Hydrate
HSP90抑制剂；6-氨基-8-[(6-碘-1,3-苯并二氧五环-5-基)硫]-N-(1-甲基乙基)-9H-嘌呤-9-丙胺一水合物
PU-H71 Hydrate
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产品编号： CPR840120
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CAS号： 1202865-65-3
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分子式：C18H21In6O2S.XH2O
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分子量：512.37
英文别名：
6-Amino-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine Hydrate
SMILES：
CCOC1=C(C=C(C=C1)S(=O)(=O)N2CCCCC2)C3=NN4C(=C(C)N=C4CCC)C(=O)=N3
参考文献：
Gewirth, D.T., et al.: J. Med. Chem., 49, 381 (2006), Taldone, T., et al.: Bioorh. Med. Chem., 17, 2225 (2009),
PU-H71 is a potent Hsp90 inhibitor (IC50 = 50 nM). Hsp90 plays a critical role in modulating the activity of many cell signaling proteins and are an attractive target for anti-cancer therapeutics. Studies indicate that Hsp90 inhibitors may serve as potential anti-Parkinson′s disease.
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