Ponatinib
普纳替尼
Ponatinib
普纳替尼
Ponatinib
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产品编号： CPR688250
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CAS号： 943319-70-8
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分子式：C29H27F3N6O
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分子量：532.56
英文别名：
3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzamide; AP 24534;
熔点：
>160°C (dec.)
可溶性：
DMSO, Methanol
性状：
Pale Yellow Solid
SMILES：
N1CCNCCCN(CCNCCC1)CC2=CC=C(C=C2)CN3CCNCCCNCCNCCC3
储存条件：
Amber Vial, Refrigerator, Under inert atmosphere
参考文献：
Weisberg, E., et al.: Cancer Cell, 7, 129 (2005), Zhou, T., et al.: Chem. Biol. Drug Des., 70, 171 (2007), Quintas-Cardama, A., et al.: Blood, 2009, 113, 1619 (2009),
Ponatinib (AP24534) is a novel potent, orally available small molecule multitargeted kinase inhibitor. Ponatinib inhibits both native and mutant BCR-ABL. Ponatinib is used in the treatment of chronic myeloid leukemia (CML) with BCR-ABL kinase inhibitors.
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