PLX-4720
突变体B-RAF抑制剂；N-[3-[(5-氯-1H-吡咯并[2,3-b]吡啶-3-基)羰基]-2,4-二氟苯基]-1-丙烷磺酰胺
PLX-4720
突变体B-RAF抑制剂；N-[3-[(5-氯-1H-吡咯并[2,3-b]吡啶-3-基)羰基]-2,4-二氟苯基]-1-丙烷磺酰胺
PLX-4720
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产品编号： CPR635000
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CAS号： 918505-84-7
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分子式：C17H14ClF2N3O3S
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分子量：413.83
英文别名：
N-[3-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide
SMILES：
Cl.CC(C(OCOC(C1C(C)(C)S[C@@H]2[C@@H](C(=O)N12)NC([C@@H](C1C=CC=CC=1)N)=O)=O)=O)(C)C
参考文献：
Conner, S., et al.: J. Biol. Chem., 278, 34548 (2003), Dumaz, N., et al.: Cancer Res., 66, 9483 (2006), Salerno, P., et al.: J. Clin. Endocrinol. Metab., 95, 450 (2010),
PLX4720 is a selective inhibitor of mutant B-RAF and its analog, PLX4032, is currently undergoing clinical trials in melanoma.
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