PK-11195
PBR配体；1-(2-氯苯基)-N-甲基-N-(1-甲基丙基)-3-异喹啉甲酰胺
PK 11195
PBR配体；1-(2-氯苯基)-N-甲基-N-(1-甲基丙基)-3-异喹啉甲酰胺
PK 11195
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产品编号： CPR571500
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CAS号： 85532-75-8
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分子式：C21H21ClN2O
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分子量：352.86
英文别名：
RP 52028；1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide
SMILES：
C(NC1C=CC=CC=1B(O)O)(=O)C(C)(C)C
参考文献：
Azarashvili, T. et al.: J. Neurochem., 94, 1054 (2005); Le Fur, G. et al.: Life Sci., 33, 449 (1983); Walter, R.B. et al.:
PK 11195 is a high affinity peripheral benzodiazepine receptor (PBR) ligand. PK 11195 has been shown to regulate protein phosphorylation in rat brain mitochondria under control of Ca2+. PK11195 promotes mitochondrial apoptosis and blocks P-glycoprotein (Pgp)-mediated drug efflux to chemosensitize cancer cells.
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