马来酸匹杉琼
马来酸匹杉琼
米托蒽醌类似物;马来酸匹杉琼
Pixantrone Dimaleate
米托蒽醌类似物;马来酸匹杉琼
Pixantrone Dimaleate
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产品编号: CPR552500
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CAS号: 144510-96-3
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分子式:C17H19N5O2
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分子量:325.37
英文别名:
6,9-Bis[(2-aminoethyl)amino]benz[g]isoquinoline-5,10-dione;
SMILES:
Cl.COC(=O)C1C(=CC=CC=1)C(=O)C2=CC=C(OCCN3CCCCC3)C=C2
参考文献:
Cavalletti, E. et al.: Invest. New Drugs, 25, 187 (2007); Gonsette, R.E. et al.: J. Neurol. Sci., 223, 81 (2004); Colombo, R. et al.: Electrophoresis, 30, 1418 (2009);
Pixantrone is an antineoplastic drug belonging to group of antitumor antibiotics. Pixantrone is an anlogue of Mitoxantrone (M373425) and is just as potent in the treatment of multiple sclerosis with fewer toxic effects on cardiac tissue. Studies suggest that Pixantrone significantly reduces amyloid beta (A beta(1-42)) neurotoxicity, a mechanism implicated in Alzheimer's disease.
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