PhiKan-083 盐酸盐
9-乙基-N-甲基-9H-咔唑-3-甲胺盐酸盐
PhiKan-083 Hydrochloride
9-乙基-N-甲基-9H-咔唑-3-甲胺盐酸盐
PhiKan-083 Hydrochloride
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产品编号： CPR338500
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CAS号： 880813-36-5
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分子式：C16H19ClN2
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分子量：274.79
英文别名：
9-Ethyl-N-methyl-9H-carbazole-3-methanamine Hydrochloride
SMILES：
C1(C2(C(F)(F)F)N=N2)C=CC=CC=1
参考文献：
Vousden, K., et al.: Nat. Rev. Cancer., 2, 594 (2002); Olivier, M., et al.: Hum. Mutat., 19, 607 (2002); Ang, H., et al.: J. Biol. Chem., 281, 21934 (2006); Wiman, et al.: Oncogene, 29, 4245 (2010);
PhiKan-083 is a p53 stabilizing agent. PhiKan-083 preferentially binds mutated (Y220C) p53 over wild-type p53 at a site distinct from functional DNA/protein interaction regions. PhiKan-083 slows rate of thermal denaturation of p53-Y220C.
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