PHA-793887
CDK抑制剂；3-甲基-N-[1,4,5,6-四氢-6,6-二甲基-5-[(1-甲基-4-哌啶基)甲酰]吡咯并[3,4-c]吡唑-3-基]丁酰胺
PHA 793887
CDK抑制剂；3-甲基-N-[1,4,5,6-四氢-6,6-二甲基-5-[(1-甲基-4-哌啶基)甲酰]吡咯并[3,4-c]吡唑-3-基]丁酰胺
PHA 793887
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产品编号： CPR294480
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CAS号： 718630-59-2
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分子式：C19H31N5O2
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分子量：361.48
英文别名：
3-Methyl-N-[1,4,5,6-tetrahydro-6,6-dimethyl-5-[(1-methyl-4-piperidinyl)carbonyl]pyrrolo[3,4-c]pyrazol-3-yl]butanamide
SMILES：
OCCO[C@@H]1CC[C@@H](N2C(=O)C(C3=CC=C(OC)N=C3)=CC3=C(N=C(N=C23)N)C)CC1
参考文献：
Alzani, R. et al.: Exp. Hematol., 38, 259 (2010); Locatelli, G. et al.: Mol. Cancer Ther., 9, 1265 (2010); Brasca, M. et al.: Bioorg. Med. Chem., 18, 1844 (2010);
PHA-793887 is a potent CDK (cyclin-dependent kinase) inhibitor. Recent studies shows that PHA-793887 has promising therapeutic activity against acute leukemias in vitro and in vivo. PHA-793887 was used to successfully modulate E2F transcriptional factor-dependent cell cycle, DNA replication, mitosis and apoptosis related gene in both tumors and skin biopsy from patients with solid tumors.
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