PHA-543613 盐酸盐
α7nAChR激动剂；N-[(3R)-1-氮杂双环[2.2.2]辛-3-基]呋喃并[2,3-c]吡啶-5-甲酰胺盐酸盐
PHA-543613 Dihydrochloride
α7nAChR激动剂；N-[(3R)-1-氮杂双环[2.2.2]辛-3-基]呋喃并[2,3-c]吡啶-5-甲酰胺盐酸盐
PHA-543613 Dihydrochloride
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产品编号： CPR294400
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CAS号： 478148-58-2
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分子式：C15H19Cl2N3O2
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分子量：344.24
英文别名：
N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide Dihydrochloride；PHA 543613E
熔点：
>300˚C
可溶性：
DMSO, Methanol
性状：
Tan Solid
SMILES：
O=C1CCC2C=C(NC3=NC=C(C(F)(F)F)C(NCC4C=CC=C(S(=O)(C)=O)C=4)=N3)C=CC=2N1
储存条件：
Refrigerator
参考文献：
Shaffer, C.L. et al.: Drug Metab. Dispos., 35, 1188 (2007); Wishka, D.G. et al.: J. Med. Chem., 49, 4425 (2006); Acker, B.A. et al.: Bioorg. Med. Chem. Lett., 18, 3611 (2008);
PHA-543613 is a potent selective α7 nAChR agonist. Nicotinic acetylcholine receptors are ligand-gated ion channels activated by nicotine, expressed in multiple tissues, with high functional expression in brain. The homomeric subtype α7 is a potential therapeutic target for cognitive deficits in schizophrenia and Alzheimer′s disease. PHA-543613 is active in both in vitro (binding, calcium flux, patch-clamp) and in vivo (auditory gating, novel object recognition) assays.
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