PF-4800567 盐酸盐
CK1ε抑制剂；3-[(3-氯苯氧基)甲基]-1-(四氢-2H-吡喃-4-基)-1H-吡唑并[3,4-d]嘧啶-4-胺盐酸盐
PF 4800567 Hydrochloride
CK1ε抑制剂；3-[(3-氯苯氧基)甲基]-1-(四氢-2H-吡喃-4-基)-1H-吡唑并[3,4-d]嘧啶-4-胺盐酸盐
PF 4800567 Hydrochloride
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产品编号： CPR294035
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CAS号： 1391052-28-0
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相关CAS号：1188296-52-7（单体）
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分子式：C17H19Cl2N5O2
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分子量：396.27
英文别名：
3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Hydrochloride
参考文献：
Behrend, L., et al.: Oncogene, 19, 5303 (2000), Badura, L., et al.: J. Pharmacol. Exp. Ther., 322, 730 (2007), Arora, S., et al.: Cancer Res., 69, 1910 (2009), Walton, et al.: J. Pharmacol. Exp. Ther., 330, 430 (2009),
PF 4800567 is a selective casein kinase 1ε inhibitor; displays 22-fold greater potency towards CK1ε than CK1δ (IC50 values are 32 and 711 nM for CK1ε and CK1δ respectively). ATP competitive. Displays minimal effect on the circadian clock.
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