PF-4708671
S6K1抑制剂；2-[[4-(5-乙基-4-嘧啶基)-1-哌嗪基]甲基]-6-(三氟甲基)-1H-苯并咪唑
PF 4708671
S6K1抑制剂；2-[[4-(5-乙基-4-嘧啶基)-1-哌嗪基]甲基]-6-(三氟甲基)-1H-苯并咪唑
PF 4708671
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产品编号： CPR294010
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CAS号： 1255517-76-0
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分子式：C19H21F3N6
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分子量：390.41
英文别名：
2-[[4-(5-ethyl-4-pyrimidinyl)-1-piperazinyl]methyl]-6-(trifluoromethyl)-1H-benzimidazole
熔点：
189-191°C
可溶性：
DMSO, Methanol
性状：
Pale purple Solid
SMILES：
[Cl-].COC1C(O)=C(O)C=C(C2=[O+]C3=CC(=CC(O)=C3C=C2O)O)C=1
储存条件：
-20˚C Freezer
参考文献：
Pearce, L.R. et al.: Biochem. J., 431, 245 (2010);
PF-4708671 is a highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). PF-4708671 inhibits S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect on highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases.
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