PF-670462-d11
CK1ε/CK1δ抑制剂内标物；4-[1-环己基-4-(4-氟苯基)-1H-咪唑-5-基]-2-嘧啶胺-d11 盐酸盐
PF-670462-d11
CK1ε/CK1δ抑制剂内标物；4-[1-环己基-4-(4-氟苯基)-1H-咪唑-5-基]-2-嘧啶胺-d11 盐酸盐
PF-670462-d11
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产品编号： CPR293962
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CAS号： 1794885-93-0
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相关CAS号：950912-80-8（未标记）
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分子式：C19H11D11Cl2FN5
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分子量：421.38
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EINECES：205-900-9
英文别名：
4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine-d11 Dihydrochloride
SMILES：
C1=C2C3=C(C4C5C(=CC=CC2=5)C=CC=4)C=CC=C3C=C1
参考文献：
Bryant, D.D. et al.: Psychopharmacology, 203, 703 (2009); Badura, L. et al.: J. Pharmacol. Exp. Therap., 322, 730 (2007); Sprouse, J. et al.: Psychopharmacology, 210, 569 (2010):
Labelled analogue of PF 670462, a potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor. PF 670462 has been shown to inhibit PER protein nuclear translocation causing phase shifts in circadian rhythms. PF 670462 attenuates methamphetamine-stimulated locomotion in vivo.
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