PF-670462
CK1ε/CK1δ抑制剂；4-[1-环己基-4-(4-氟苯基)-1H-咪唑-5-基]-2-嘧啶胺盐酸盐
PF-670462
CK1ε/CK1δ抑制剂；4-[1-环己基-4-(4-氟苯基)-1H-咪唑-5-基]-2-嘧啶胺盐酸盐
PF-670462
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产品编号： CPR293960
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CAS号： 950912-80-8
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分子式：C19H22Cl2FN5
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分子量：410.32
英文别名：
4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine Dihydrochloride
SMILES：
C1=CC=C([Si]2([Si](C3=CC=CC=C3)(C3=CC=CC=C3)[Si](C3=CC=CC=C3)(C3=CC=CC=C3)[Si](C3=CC=CC=C3)(C3=CC=CC=C3)[Si]2(C2=CC=CC=C2)C2=CC=CC=C2)C2=CC=CC=C2)C=C1
参考文献：
Bryant, D.D. et al.: Psychopharmacology, 203, 703 (2009); Badura, L. et al.: J. Pharmacol. Exp. Therap., 322, 730 (2007); Sprouse, J. et al.: Psychopharmacology, 210, 569 (2010):
PF 670462 is a potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor. PF 670462 has been shown to inhibit PER protein nuclear translocation causing phase shifts in circadian rhythms. PF 670462 attenuates methamphetamine-stimulated locomotion in vivo.
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