PF-3644022
MK2活性抑制剂；(10R)-9,10,11,12-四氢-10-甲基-3-(6-甲基-3-吡啶基)-8H-[1,4]二氮杂卓并[5',6':4,5]噻吩并[3,2-f]喹啉-8-酮
PF-3644022
MK2活性抑制剂；(10R)-9,10,11,12-四氢-10-甲基-3-(6-甲基-3-吡啶基)-8H-[1,4]二氮杂卓并[5',6':4,5]噻吩并[3,2-f]喹啉-8-酮
PF-3644022
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产品编号： CPR293825
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CAS号： 1276121-88-0
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分子式：C21H18N4Os
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分子量：374.46
英文别名：
(10R)-9,10,11,12-Tetrahydro-10-methyl-3-(6-methyl-3-pyridinyl)-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one
参考文献：
Hegen, M., et al.: J. Immunol., 177, 1913 (2006), Anderson, D., et al.: J. Med. Chem., 50, 2647 (2007), Goldberg, D., et al.: Bioorg. Med. Chem. Lett., 18, 938 (2008), Burnette, B., et al.: Pharmacology, 84, 42 (2009), Mourey, et al.: J. Pharmacol. Exp. T
PF-3644022 is a potent freely reversible ATP-competitive compound that inhibits MK2 activity (Ki = 3 nM) with good selectivity when profiled against 200 human kinases. PF-3644022 is a benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor α production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation.
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