PF-431396
FAK/PYK2抑制剂；N-[2-[[[2-[(2,3-二氢-2-酮基-1H-吲哚-5-基)氨基]-5-(三氟甲基)-4-嘧啶基]氨基]甲基]苯基]-N-甲基甲磺酰胺
PF 431396
FAK/PYK2抑制剂；N-[2-[[[2-[(2,3-二氢-2-酮基-1H-吲哚-5-基)氨基]-5-(三氟甲基)-4-嘧啶基]氨基]甲基]苯基]-N-甲基甲磺酰胺
PF 431396
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产品编号： CPR218290
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CAS号： 717906-29-1
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分子式：C22H21F3N6O3S
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分子量：506.5
英文别名：
N-[2-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]-N-methylmethanesulfonamide
参考文献：
Han, et al.: J. Biol. Chem., 284 13193 (2009), Allen, et al.: J. Med. Chem., 53 4332 (2010),
PF 431396 is a dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively). Promotes osteoblast recruitment and activity, and stimulates bone formation in ovariectomized rats.
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