PD-144418 草酸盐
σ1配体；1,2,3,6-四氢-5-[3-(4-甲苯基)-5-异恶唑基]-1-丙基吡啶草酸盐
PD 144418 Oxalate
σ1配体；1,2,3,6-四氢-5-[3-(4-甲苯基)-5-异恶唑基]-1-丙基吡啶草酸盐
PD 144418 Oxalate
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产品编号： CPR217520
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CAS号： 154130-99-1
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分子式：C20H24N2O5
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分子量：372.41
英文别名：
1,2,3,6-Tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propylpyridine Oxalate
SMILES：
CCCCCCCC/C=C\CCCCCCCCCCCCCC(=O)NC([C@H](O)[C@H](O)CCCCCCCCCCCCCC)CO[C@@H]1C(O)[C@@H](O)[C@@H](O)C(CNC(C)=O)O1
参考文献：
Walker, J., et al.: Pharmacol. Rev., 42, 355 (1990); Akunne, et al.: Neuropharmacology, 36, 51 (1997); Jbilo, O., et al.: J. Biol. Chem., 272, 27107 (1997),
PD 144418 is high affinity, selective σ1 ligand (Ki values are 0.08 and 1377 nM for σ1 and σ2 respectively). PD 144418 displays no significant activity at a wide range of other receptors, ion channels and enzymes. PD 144418 antagonizes mescaline-induced scratching in mice following i.p. administration.
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