PCI-34051
HDAC8抑制剂；N-羟基-1-(4-甲氧苯基)-1H-吲哚-6-甲酰胺
PCI-34051
HDAC8抑制剂；N-羟基-1-(4-甲氧苯基)-1H-吲哚-6-甲酰胺
PCI-34051
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产品编号： CPR216600
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CAS号： 950762-95-5
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分子式：C17H16N2O3
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分子量：296.32
英文别名：
N-hydroxy-1-(4-methoxybenzyl)-1H-indole-6-carboxamide
SMILES：
FC1C=CC(C2CCN(C)CC2CO)=CC=1
参考文献：
Balasubramanian, S. et al.: Leukemia, 22, 1026 (2008); Pipalia, N.H. et al.: Proc. Nat. Acad. Sci. USA, 108, 5620 (2011);
PCI-34051 is a potent, histone deacetylase 8 (HDAC8)-specific inhibitor. PCI-34051 induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias. PCI-34051 did not affect other hematopoietic or solid tumor lines. PCI-34051 treatment has been shown to significantly reduce cholesterol accumulation in Niemann-Pick type C1 gene mutated human fibroblast.
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