PAC-1-d8
半胱天冬酶-3激活剂内标物；胱天蛋白酶原-1-d8；
PAC-1-d8
半胱天冬酶-3激活剂内标物；胱天蛋白酶原-1-d8；
PAC-1-d8
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产品编号： CPR132002
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CAS号： 1287241-26-2
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相关CAS号：1044929-62-5 (未标记)
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分子式：C23H20D8N4O2
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分子量：400.54
英文别名：
Procaspase Activating Compound 1-d8
参考文献：
Slee, E., et al.: J. Biol. Chem., 276, 7320
Labelled PAC-1 is a caspase 3 activator. Caspase activation is a key strategy in cancer therapy. Caspase 3 is a key executioner caspase and direct effector of apoptosis. Hallmark of many cancers is the circumvention of signal in the activation of executioner caspases and loss of apoptotic response. EC50 for caspase 3 activation = 0.33 μM and caspase 7= 4.5 μM. The IC50 for apoptosis induction = 0.92 μM. Elevated caspase 3 level in cancerous cell lines and tissues allows PAC-1 to selectively induce apoptosis in tissues.
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