NSC-33994-d4
JAK2酪氨酸激酶抑制剂内标物；(E)-4,4'-(1,2-二乙基-1,2-乙烯二基)双[2-[(二乙氨基)甲基]苯酚-d4
NSC-33994-d4
JAK2酪氨酸激酶抑制剂内标物；(E)-4,4'-(1,2-二乙基-1,2-乙烯二基)双[2-[(二乙氨基)甲基]苯酚-d4
NSC-33994-d4
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产品编号： CNR900302
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CAS号： 1795134-33-6
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相关CAS号：82058-16-0(未标记)
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分子式：C28H38D4N2O2
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分子量：442.67
英文别名：
(E)-4,4'-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylamino)methyl]phenol-d4
SMILES：
[Na+].CO[C@@H]1[C@H]([C@H]([C@H](OC2=CC=C3C(=C2C)OC(C(=C3O)NC(=O)C2=CC(C/C=C(/C)\C)=C(C=C2)[O-])=O)OC1(C)C)O)OC(N)=O
参考文献：
Tanner, J., et al.: J. Biol. Chem., 270, 6523 (1995), Rane, S., et al.: Oncogene, 19, 5662 (2000, Verma, A., et al.: Cancer Metastasis Rev., 22, 423 (2003), Levine, R., et al.: Cancer Cell., 7, 387 (2005), Kiss, et al.: Bioorg. Med. Chem. Lett., 19, 3598
Labelled NSC-33994 (N900300). NSC-33994 is novel inhibitor of JAK2 tyrosine kinase (Janus kinase 2 ). Janus kinase 2 (JAK2) plays a crucial role in the pathomechanism of myeloproliferative disorders and hematological malignancies.
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