NSC-33994
JAK2酪氨酸激酶抑制剂；(E)-4,4'-(1,2-二乙基-1,2-乙烯二基)双[2-[(二乙氨基)甲基]苯酚
NSC-33994
JAK2酪氨酸激酶抑制剂；(E)-4,4'-(1,2-二乙基-1,2-乙烯二基)双[2-[(二乙氨基)甲基]苯酚
NSC-33994
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产品编号： CNR900300
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CAS号： 82058-16-0
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分子式：C28H42N2O2
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分子量：438.65
英文别名：
(E)-4,4'-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylamino)methyl]phenol
SMILES：
FC(OC(C(OC1=CC=C(NC(NC(C2=C(F)C=CC=C2F)=O)=O)C=C1Cl)(F)F)F)(F)F
参考文献：
Tanner, J., et al.: J. Biol. Chem., 270, 6523 (1995), Rane, S., et al.: Oncogene, 19, 5662 (2000, Verma, A., et al.: Cancer Metastasis Rev., 22, 423 (2003), Levine, R., et al.: Cancer Cell., 7, 387 (2005), Kiss, et al.: Bioorg. Med. Chem. Lett., 19, 3598
NSC-33994 is novel inhibitor of JAK2 tyrosine kinase (Janus kinase 2 ). Janus kinase 2 (JAK2) plays a crucial role in the pathomechanism of myeloproliferative disorders and hematological malignancies.
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