trans-Ned-19
NAADP拮抗剂；(1R,3S)-1-[3-[[4-(2-氟苯基)-1-哌嗪基]甲基]-4-甲氧苯基]-2,3,4,9-四氢-1H-吡啶并[3,4-b]吲哚-3-羧酸
trans-Ned-19
NAADP拮抗剂；(1R,3S)-1-[3-[[4-(2-氟苯基)-1-哌嗪基]甲基]-4-甲氧苯基]-2,3,4,9-四氢-1H-吡啶并[3,4-b]吲哚-3-羧酸
trans-Ned-19
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产品编号： CNR388750
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CAS号： 1354235-96-3
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分子式：C30H31FN4O3
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分子量：514.59
英文别名：
(1R,3S)-1-[3-[[4-(2-Fluorophenyl)-1-piperazinyl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-Pyrido[3,4-b]indole-3-carboxylic Acid;
熔点：
168-173°C
可溶性：
Methanol
性状：
Dark Yellow Solid
SMILES：
BrC1=CC=C(NC(C(NC2CC(C)(C)NC(C)(C)C2)=O)=O)C=C1
储存条件：
Refrigerator
参考文献：
Rosen, D. et al.: J. Biol. Chem., 284, 34930 (2009); Naylor, E. et al.: Nat. Chem. Biol., 5, 220 (2009); Thai, T.L. et al.: Am. J. Physiol. Renal Physiol., 297, F510 (2009);
trans-Ned-19 is a cell permeable and potent nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. trans-Ned-19 inhibits NAADP-mediated Ca2+ release (IC50 = 6 nM) and also inhibits [32P]NAADP binding (IC50 = 0.4 nM). trans-Ned-19 can be used as
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