盐酸纳呋拉啡-d3
盐酸纳呋拉啡-d3
Nalfurafine-d3 Hydrochloride
盐酸纳呋拉啡-d3
Nalfurafine-d3 Hydrochloride
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产品编号： CNR255602
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CAS号： 152658-17-8
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分子式：C28H30D3ClN2O5
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分子量：516.04
英文别名：
(2E)-N-[(5α,6β)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-yl]-3-(3-furanyl)-N-methyl-2-propenamide Hydrochloride; (-)-17-(Cyclopropylmethyl)-3,14β-
dihydroxy-4,5α-epoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan Hydrochloride; Rem
参考文献：
Fujii, H., et al.: Bioorg. Med. Chem., 12, 4133 (2004); Mori, T., et al.: Life Sci., 75, 2433 (2004); Fujii, H., et al.: Curr. Med. Chem., 13, 1109 (2006); Nagase, H., et al.: Bioorg. Med. Chem. Lett., 20, 6302 (2010);
Nalfurafine hydrochloride was launched on March of 2009 in Japan as the first in class non-narcotic opioid drug for intractable itch caused by hemodialysis. It showed significant opioid κ-agonist activity and induced neither aversion nor preference in rat
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